Can I use Unity when yes how?
It really depends on what you're going to make.
Generally you should should set your Sprites "Filter Mode" to "Point (no filter)" and "compression" to "none", so they stay sharp and download the "2D Pixel Prefect" Package and add a "pixel perfect camera" component to your camera. Set the reference resolution to 84x48 (or the other way around) and enable upscaling.
There is a bunch of other things you can do and add, but this should get you the minimal requirement for the look.