It is possible, you just have to get how the card game works :3 took me like 3 runs to finally beat the clown... play the bigger cards first, leave the wildcards and the smaller numbers (if you have any) last. This is my strategy and it usually works c: Good luck!!!
Depends, I did lowest numbers first working my way up leaving wildcards to last and that worked quite well.
From my experience, the clown nearly always has two or more wildcards so he can get out of you playing high for the first part of the hand so just focus on getting rid of the low numbers until you need a wildcard.