Never
Important questions: will there be a HAREM? And is the content forced or can it be avoided? This is what I mean about some fetishes or tags that are sometimes presented in the game that are not to everyone's liking (lesbian, ntr, femdom, etc)
It's your decision, if you don't like "Lesbian" just follow a different Path, same as for Harem.
NTR is never in a game from me, same as femdom, domination etc.