Thanks for the question- the truth is I am not completely sure, but honestly think it should be able to (approximately 85% sure). On the back-end of things we are using a set of libraries and functions called Lab Streaming Layer (in particular super helpful codes from LSL4Unity) to handle the data transfer to/from Unity and MATLAB. The LSL data streams use a broadcast/subscription model so they can take any name you'd want. I do know we can have multiple LSL streams produced so it would just be a matter of subscribing to the right stream and having at least 2 instances of MATLAB open to process the 2 streams. Might be able to tinker with it throughout the jam to be sure. So in summary - haven't tried it yet but love the idea!