As a non-game dev, I do not know how difficult this would be to implement, but what if every 4 or 5 turns, you were guaranteed at least one health item? (4 rounds at 2 damage each means you die on the 5th attack unless you can heal.)
As a game dev, this is very possible, but I personally think it would be more interesting to make the player make conscious choices about how to build their deck. Look towards other roguelike deck builders (slay the spire, cough cough) on how to execute this well. But this is an awesome foundation and I really do hope Amsern Studio keeps developing this, I'd gladly pay money for a more expansive and polished version of this. Awesome!