I like your game and I like your concept. The art style reminds me of Roadwarden. I’d like to see what you do with it after the jam.
I did find it confusing to know what to do to treat all of the diseases. The people who haven’t relieved themselves in a while implies that they need water to balance out the “common humors” (if I understand your manual correctly) but there’s no obvious way to do this. It’s also not obvious how many ingredients to use to create effective potions.
Finally, after playing it long enough, I ran into what I assume is a UI bug, where descriptions of NPCs did not update no matter what buttons I clicked.
Still, a good game. I hope you keep going with it.