So far, the popping mechanic feels fairly reasonable. It does mean that certain methods can't be used for inflation anymore, since they drastically overshoot maximum capacity, but that's good! Means you have to do things safe.
As for the technical side of things I haven't really encountered any major bugs that were big hangups... I suppose there is the fact that a character can still pop again after getting out of the hospital, presumably because the status effects of the pills haven't worn off yet. Perhaps a status cleanse would be appropriate?
Also, the experiment scene and feeding scenes are excellent! The new outfits are very cute too.