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Guesses and suspicions are not really helpful, especially when there is a dedicated place for customers to ask questions from the staff, and another place for customers to request features.

If one cannot expect a response from the staff, that is another matter, not related to the specific feature being requested.

especially when there is a dedicated place for customers to ask questions from the staff

I am not aware of such a place. This is public community. Users talk to users here. That the founder of Itch sometimes posts here, does not change this.

Share your ideas and feedback for things you'd like to see itch.io do.

Share. As in: discuss. 

So the only answer to such topics will come from other users. What would you expect in such a discussion? I voiced my opinion about the matter, why it might not be already implemented and why it might not be as helpful as it seems. You can voice your opinion why it is a good and needed feature*. Maybe you can convince me, and I would use such capabilites more often in the future. Maybe you can convince others and they hit the feature request button in the feedback button. Search is currently being overhauled, maybe multiple tag exclusion is on the roadmap.

* That might be interesting. A showcase where such a feature will help you find the games you seek.

Search is currently being overhauled, maybe multiple tag exclusion is on the roadmap.

A good example of a really unhelpful comment.

Sharing a suspicion, for example, that all the people that  have asked for multiple tag exclusion only want to exclude horror, and that they can use a bookmark for that, is also not helpful.

It is clear that you do not understand the usefulness of this feature, and if you could be honest, that will not change. You might send hundreds more words to restate your opinion on the matter. Please know that if I don't reply, it's not because I am afraid, or dumbstruck. You and I have made our opinions clear on this matter. Let's hear from someone who has a say in it.

It is clear that you do not understand the usefulness of this feature

I asked you to illustrate the usefulness. Make me understand. Give me another perspective.

You also did not answer my question what you meant with tag inclusion.

You also did not answer my question about your game evaluation quality thingy.

As for sharing opinions, please realize where you posted. "Share your ideas" is this communitiy's headline.

Let's hear from someone who has a say in it.

Now that would be something. The nearest I could find is this https://itch.io/t/3818776/new-search-backend  "Refining our search system is an ongoing task".