Howdydiddlydeedly! first off, I love the idea of Haemoglobin Simulator 2020! XD
there are many deliciously splendiferous root concepts I have seen video games developed off of which is in itself encouraging in the industry! Talking triple A titles, one that I do love (on the core concept level) is the Watchdogs games. The idea of such technological vulnerability in learned hands is something that is a sobering thought in this day and age O_O.
With regards to games that you find on itch.io, there is one particular game I am holding high which is called "This Is Your Life Now" from More Mountains ;) This is a brilliantly simple game on the surface but as I found playing it, iit is actually very thought provoking!
In the game you play from childhood right to old age and death by walking forward! Simple right? Well, as you walk towards the grave, you will gain different life events like gaining your fiorst love, gaining bullies, and so forth. Each playthrough as well allows for such different possibilities as you can in the game at points choose whether or not you will take on certain events.