I dunno. There is a mac version though, haven't tested it myself.
Viewing post in Vanessa's Substitution Classic comments
so it is hard but if you need a tutorial here's
how
1. download venessa's substitution for mac
2. right click it and click open package contents click contents folder then MacOS you will find the textedit file
3. open terminal and type or copy and paste this
chmod +x /Users/{Username}/Downloads/VanSubs_Mac.app/Contents/MacOS/Vanessa\'s\ Substitution
now launch the game there its fixed
so the problem is that the macOS file inside isn't executable
hope this helps also if type your usernme like this dyawmne99 no spaces no capitals