Interesting concept. I don't know that I entirely understood how best to use all the tools at my disposal. I wonder if things would have felt more intuitive if you could e.g. target specific areas with lockdowns and things so that there is some kind of visual indication of what's happening? It basically felt like nothing I did made much of a difference, and then eventually I lost.
I.e. I'd have liked to have seen some more exaggerated effects so that the implications of my choices were a bit more obvious.