I'm a fully blind player and I'm delighted to say that the "self voicing" and even better the "clipboard voicing" features built into Renpy work great with this game, except for two areas.
1. I can't edit the name of my dragon. Pressing keys to type just activates UI commands, and I can't press enter or space to put my cursor into the edit field because doing so progresses the story.
2. When choosing places to attack in my war room in act 3, the icons representing the various regions are only pictures with no text labels for the self voicing to read, so I have to randomly press enter on one of them, see what it says, go back, try to remember how many presses of the down arrow to do to find it again, and then pick it that way.
Still 90% accessible though, and I really do appreciate that!