Don't worry, honestly, I don't think I fully understood everything, but I'll respond based on what I got. Most people use Ren'Py because, in quotes, it's the "easiest" or, in some way, the best tool to create these types of games or visual novels, however you want to call them. With Ren'Py, you code and build the game. Even if you're a good artist, you'll still need to use Photoshop or another tool to draw and create renders. Then, in Honey Select and Neo Studio, you'd create character renders, or Koikatsu or DAZ for more realistic games.
Honestly, even now I'm a bit confused about what I understood and how I'm responding, haha. There are other programs like RPG Maker, which is for making more complex games, but I guess Ren'Py is ideal for starting out. The most famous games I've come across were made with Ren'Py. Honestly, I can't think of any other explanation. Sorry if things sound a bit weird or if I didn’t fully answer your question.