Great to see you're incorporating feedback from previous DDs. Love how the watchers have different spawn circles depending on their appearance. Mines and fire watchers spawn circles are way too similar still (I noticed they are red and yellow when I rewatched the VOD, but I didn't notice that during gameplay). The red barrels are much, much more noticeable, which is great - now I can die to enemies and not to barrels!
Upgrades are a VERY welcome addition, so is the tutorial. I also dig the "Hold the button to mix stuff", also very welcome.
The only thing of note right now - all enemies are weak to poison, so you can ignore mixing most of the time. Though I guess this won't be an issue once there are more enemies.
Keep it up, great stuff!