That is drastically improved, though still very sluggish...that is so weird, this is the first time I've seen it drop in performance because of permissions. To further increase performance, you could try moving its directory over to your other drive, and also mess with compatibility settings by right clicking the exe file and opening properties. My computer thinks it should run in compatibility mode with Windows XP Service Pack 2, which is probably because GameMaker 8.1 is a dated engine at this point, though I have never had the performance drops you are facing.
Is the drive it is currently on a solid-state or regular hard drive?
Thanks very much for helping me troubleshoot it.