Any thoughts / suggestions to modifying this to play the video game Dredge as a ttrpg?
I haven't played Dredge yet, but I think this is as simple as reskinning and renaming stuff. Change the Animals to monsters, maybe tweak Making Camp so that it's Making Port, change the Equipment to boat upgrades, and I think you're in the right ballpark.
My understanding of Dredge is that a lot of what makes it work is its atmosphere, and it's easy to change Rodreel's atmosphere without having to also change its mechanics.