Tried running it on my Windows, it launches to the menu, but it seems a few of the buttons are blank.
Tried running it on VR through my HTC vive, no dice, and even mouse+keyboard mode doesn't run. You can hear the click SFX, but that's it. Only stays in the menu. 
I would try to rename the user folder of the game that you find in:
C:\Users\<yourUsername>\AppData\LocalLow\ZnelArts\TheVillainSimulator
Then the folder is recreated with default settings on the next game start.
Depending on from which version you updated you can get some really weird effects.
Be aware that this removes all your settings and whatever else is saved!
You can of course always change the name back or copy individual files from the old folder in case that the renaming resolved the issue.
