You need to start clicking after the minigame starts. I had trouble with the "question" minigame too and this worked for me.
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Thanks, but it still doesn't work for me... The game does not react to my input whatsoever.
I have tried: Clicking (spamming), Clicking and holding and drag and drop. And all that after the minigame starts and also before the minigame starts. I have tried the game in the Google Chrome browser with adblock disabled, in the Opera browser and in the Edge browser. But to no avail... I can only play the match-3 game on the right side without issues but the rest on the left side does not react to any of my mouse input...