1) what game engine- tuned to project and hardware. Sometimes it might be easier to just use some graphics library if the project is simple but very custom. 2) you can, just optimize it well and be mindful of resources. 3) Start with a documented project->fit tools for purpose-> learn tools. 4) it's your brain that works, your eyes and hands. It is more important to know what you are doing. As an artist you should learn to see the world differently. 5) find ways to overcome obstacles. Being in a group helps to actually complete something. I can teach you some pixel art plus other related things if you are willing to go the way with:
https://itch.io/t/4542360/art-looking-for-collaborators-to-form-new-project