I have it working with Lutris pretty smoothly, with the following settings:
Game Info Tab > Runner = Wine
Game Options Tab > Executable = Path to the 64-bit exe file downloaded from ItchIO
Runner Options Tab > Wine Version = Lutris-5.7-x86_64
Runner Options Tab > Enable DXVK = On
Runner Options Tab > Windowed (Virtual Desktop) = On
Runner Options Tab > Virtual Desktop Resolution = Set to your native desktop resolution
It runs perfectly with these settings for me, no issues so far