Yes. However, I believe all of them are based around your Sanity. If you go Insane (No Sanity left), you lose, but I won't gurantee there aren't any other ways; I don't remember everything. All you have to do is sleep or use a Sanity potion to regain some of your Sanity.
I use save files to intentionally go insane around certain things because they have interesting endings.
***Spoilers***
Such as with a Raptor, if you fight it with 10 or less sanity left, and tease it enough to make it horny, but then lose, you will go insane and become a slave for them, at which point it will cycle through a short summary of your 'new life' before taking you back to the title screen.