We are looking into putting in a global option to disable all post processing effects. It sounds like the height fog effect in the Caves is causing the crash, so disabling that would potentially fix it. Make sure to follow and keep an eye out for updates.
Excellent, keep us posted! That very well could be it. Thank you for the incredible love and dedication you guys are pouring into this project! I've been fan of Vinesauce for almost 5 years now and this game is one of the most exciting things to ever come out of the charity event :)
Small edit a day later: Game also crashes for me when I enter Vinetoad Kingdom at all, possibly for the same reason as above.