Nice entry, good work!
I got just past the first kilometre before being destroyed, then the game exited - not sure if that's intended or a bug but a chance to see my score and how far I got before being booted out would have been nice!
I'm not sure many of the pickups were very useful, it wasn't always obvious what they were doing and things like speed-up (I think that's what the blue/yellow pickup is) don't seem very helpful when going faster doesn't seem to help. I'd suggest pickups that restore the train's health / armor, temporarily provide immunity, make guns more powerful (could be short-lived or permanent), temporarily stop the gun from overheating. It was also a bit non-intuitive having to right click the pickups to collect them, having them automatically fly into the player or shoot to collect/activate would have worked better imo.