Its SUCH a good game but it DOES touch on some super intense (potentially triggering) content and supernatural-esque horror hence the warnings. If that's cool with you then I HIGHLY recommend it.
Playthrough wise, my recommendation is to not play TJ's or Flynn's routes first since those are the most lore heavy and its more fun to wonder what's going on. Honestly even though it was an emotionally heavy experience the Echo team did SUCH a good job with this. Honestly my favorite VN on itch. ^u^
All the smoke room references in echo have me HOOKED on that title as it's being developed.
(P.s. Leo's route made me so emotional I literally went into the script files to try and see if there was another ending but I'm still pretty satisfied with the 'good ending' TuT)
TLDR; play it if you feel comfortable enough to handle it