Excellent artstyle and music that leave a good impression from the very main menu. I'm very curious to see what direction the gameplay will take in later iterations. At first glance I expected something along the lines of painkiller but the three strike health system and the slow reload times suggest something more tactical that could be really interesting. The only nitpicking I may point out is that it feels awkward to have to press F to pick up a weapon, and it would be more convenient to just walk over it (like you do with ammo).
Also, I love how you throw the cig at the start. It's a small thing but adds a lot of character!