Thanks! Glad you enjoyed it, and yeah, some of the content can be very obscure to find. To be fair, that's also a bit of what makes it fun imo, the fact that there's just hidden stuff all over the place, so you never know what you'll find out there. That said, I usually try to include some sort of hints, especially from the non-portrait NPC's.
For Cassie, you need to get Alissa to interrupt you and Cassie a third time. The one people miss is having to annoy Cassie (she also can't be pregnant for this)
M2F stuff, there's two places it can happen right now. One is the science lab tower experiment. The other involves getting captured in the deserted base.