I just restart when I die. I can make it into region 3 so far. Good stuff! I need to just go through the whole game and see what exists before I continue these runs.
On that note, I have some ideas for future versions, leveraging the rewind/replay system in a more interesting way. A bit radical, but it has been done before. :-)
https://github.com/olofson/koboredux/issues/560