Sure. You will need two Plugins, TDDP_MouseSystemEX and PEZ_PointAndClickInventory. To stop the flash when clicking the screen I had to go into the code to disable the flash. I do not remember which JS file I had to modify but I'm sure you can you find it in the RPGMaker Forums. For the first person perspective, the transparency was on. What you are seeing in the demo is a parallax background. I had to create this scene in Gimp (Can be done with Photoshop), then I added the events in the screen.
I hope this helps!