It depends on the type of game. 2D graphics vs 3D graphics won't make a difference
Pixel art is a different story - it's an acquired taste and polarising - some people love it and others won't touch it because it's consider dated, old-fashioned etc.
Also note that pixel art doesn't scale well, despite popular belief, you need some settings on the user's side to override the default Windows graphics. I saw that Unity has a special plugin / extension to solve that problem, but most other software I've played with doesn't have that feature and the pixel art becomes blurry when scaled up.