The time that people blindly assumed 3D was better than 2D is thank goodness behind us (it would be even better if it never existed).
Rather a good 2D game than a bad 3D game. In the end people should opt for the quality of the game itself and not if a game is 2D or 3D...
Frankly a real gamer couldn't care less about that.
Kssa has a point that 2D games are indeed quite often more friendly on the hardware, but frankly that should not be the most valid point.
Pixel Art is indeed a point of discussion, as scaling is getting an issue here. When it comes to people not wanting to touch pixel art... well the question is if you should bother about those people anyway to put it bluntly. A true gamer respects the choices a developer makes when it comes to the art choice. Of course, the question is if pixel art is the best choice for all games out there... that is not, but the same goes for 3D, vector graphics, well... anything. I mean the famous NES-tune for Mario is well-fit for Mario, but would it fit in a very extremely dark horror game... I think not... When it comes to the visual art style of a game, the same choices should be made.