It seems the All-Stars Update we just pushed fits specifically what you were looking for then! We have just pushed it, and one of the main additions we've made is the addition of 10 brand new game modes, each with different rules, weapon/item pools and even wackier modifiers! Some of them are more relaxed, while others are a bit more challenging. For example, one of the new modes, Berserk, is a axes-only game mode, where you play with half the health you normally have while enemies get to have the double.
If you get to try the new version and any of the new game modes, tell us which one you liked the most. 😉