And you don't have RPG Maker VX Ace games specifically muted in the volume mixer (right click on the volume icon and choose 'Open Volume Mixer' to open it, it lets you customize specific volumes for specific programs)? If it's not that's really weird.... Some people have reported issues where they accidentally had a bluetooth controller or something plugged in that caused problems for them so I'd advise checking if you've got a similar thing with some headphones you didn't know were plugged in? Otherwise my only suggestion would be to try to download the game from GameJolt, move over your save files, and see if that fixes the problem.... I'm really sorry that you're having issues with the sound here, I'll keep my eyes open for other solutions!