While on Linux I think OpenGL2 supports well on a Virtual Machine, I think a Windows 10 VM not so much, or at least I always had some issues on my systems, I have to use an actual installation, it seems that for the most part the Virtual machines focus on DirectX for Windows and OpenGL for Linux, and this game was made in linux.
The first ever version of QoD was OpenGL 1 which *should* work on windows Virtual machines but I had to upgrade to GL 2 after a couple years and that broke virtual machine. Try using that other version if you wanna give it a try at least, but warning it's really an old QoD version.
