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No..... Since 2018 the rate of virus infections on Mac has increased by 400%, the average threat rate on Mac's is currently 11 per device, Windows currently sits on 5.8. Under half of Mac. A note though this includes malware as well as virus's.

Source; Malwarebytes.

They used to get less, because of lower popularity but due to Mac's coming of age in the last few years there are ample threats now that there is a larger user base.

At a guess, the 32bit version is being flagged because of the way it write protects files that are in use, it is getting flagged as a crypto locker.

You can happily let the anti-virus delete the file if you intend to play the 64bit version.

The infection rate might have increased, but I haven't hear about cross-infections. The 32-bit executable included by Ren'Py is regularly flagged by antivirus software however, so that's a likely culprit.