Mono on Mac can't run it, though possibly Wine still could. I'm not interested in wasting my time on porting my engine to a shitty OS otherwise.
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I just wanted to add something here for posterity. When Apple blocked 32 bit applications from running on macOS they essentially killed Carbon for Mono, which is needed for Mono to run applications that use WinForms components. Hence me being rather salty towards the OS. (Especially that the same update locked me out of a few apps that I enjoyed using on my iMac.)