Part of our tilesets do, and part of them do not yet have official support (I'm getting them all up to date.) Urban Modern comes with a tileset that will work with many engines. I was able to import them to Unity and draw with them. You also asked about Sewer Central; it only has RPG Maker support right now. I have heard Unity has converters for RPG Maker tilesets as well, but have not tested those so can't vouch for them. More info here.
Viewing post in KR Urban Modern Tiles for RPGs comments
No trouble at all. :) Let's see...Tuscan Seaside, Elemental Dungeon (fire, water, earth, wind only), Urban Modern, Deep Ocean, technically Trees and Foliage should work out of the box, I'm about to update the Train with a compliant version too, although I'm curious how the train events might work. Then everything that was posted after Sewer Central should also work I think, so Motherlode, Mermaid, Phoenix, Egypt, Aztec, Griffin and Alien Worlds should also be ok to go. If you check the bottom of each listing, there's usually a blurb that mentions whether or not you get just the RM tiles or also ones for other engines. Adding in support for other engines is a relatively new thing for us so it's taking a bit of time to get everything up to date. We will eventually release versions for all our products, so if you see something you would like to buy now, go ahead because you'll get the update for free when it's released. :)