Thank You very much for your fast response. Sadly I have to disappoint You:
I tried to deactivate the Touch Keyboard and Handwriting Panel Service in the Task-Manager. Because of the setting of its start type (automatic) the service restarted immediately after I stopped it. So I set the start type to deactivated. After a reboot the service was deactivated.
This workaround didn't solve my problem. The game crashed again after about 15 minutes.
Then I updated my drivers (the GPU driver wasn't up to date). Stil the same problem.
There is an option in Windows 10 to let the system automatically select a tablet-mode. I changed the option to use desktop-mode only. Still the cashing problem...
My last hope was to start the game in compatibility mode Windows 7 and as Administrator. Still crashing after about 15 minutes.
I'll try to play the game on my laptop now.
Please let me know if You need any more information or if You found a solution.
BTW, my rig:
Windows 10 home 64-bit
GeForce GTX 970 (driver 388.71)
Intel Core i5-6500
8 Gb RAM
Two monitors (one for playing, one for YouTube while playing)
Creative Sound Blaster Z