Found another: "We'll have to do something about that, don't we?" ► "won't"
All right, I figured out what the game's biggest weakness is: it's that non-shield cards are attacked randomly instead of from left-to-right, right-to-left, or any other predictable order. This makes it comparatively impossible to plan out multiple turns, versus the turn-stacking that you can plan in Slay the Spire and Monster Train, which is what made them so popular. It would be a major game changer if attacks could be made predictable.
There are also no events that allow you to remove cards from your deck, which can be critical to helping make a worse hand better if you miss out on good synergistic cards.