Real strange, but the increasing difficulty is enticing! I like how that tutorial character doesn't find the amalgamation strange or out of the ordinary and generally seems unfazed.
But I found it kind of hard to pick up tools--it's not totally clear when you are hovering over one, and it is hard to tell when you've actually picked it up because the cursor usually blends into the bottle/container. And if you click twice by accident, you stop holding a tool, which you never want. If picking up tools was easier, I think the game would be a lot easier to play!
Also, I found that if there are multiple wounds that require skin and mesh, you can put skin on just one of them and eliminate the rest with just the mesh, eliminating the need to use the skin first (as long as you have put skin on at least one wound). I'm not sure if this was intentional.