ohhhhh it's awesome that you're focusing your game on accessibility--esp since you've faced those particular barriers yourself in games. haha i loooove sizing stuff down with "nearest neighbor"/point sampling... if you're looking for other ideas sometimes what i do is run an image through a dithering generator online! it's cool because it can have a pretty neat retro look, especially if i already make the image black and white. i love your take on this theme--i'm excited to see progress on this!
also--jams like these can be exhausting endeavors, but i really encourage jammers who don't have a lot of free time or ability to work for long periods to use the two weeks to figure out what's a sustainable way to make a game. shorter jams can be a bit inaccessible because it's hard to work a lot of hours at once, but i don't think burning out in two weeks is the best idea either, so don't be afraid to go at a pace that works well for you and submit whatever you have at the end of the jam, even if it's just a prototype. you're always free to update it beyond the jam. i'm wishing you luck!!