Of all the games i played so far, i will perhaps always Name VTMB Bloodlines. I cant tell you wha may top 5 or ten would be exactly, as i would have to think and compare. But i always will know that Bloodlines will be Number 1.
A lot of games got close, but none was better in my opinion. Honorable mentions: System Shock2, Deus Ex, Arcanum, Minecraft, Starcraft, Planescape Torment, Gothic, Fallout 1/2, Witcher, Hotel Dusk, Dark Souls, Monster Hunter, Castlevania, Zelda :Links Awakaning, The Riddle of Master Lu