Thanks Blair. After a lot of messing about I discovered that if you ignore the error message and click on the new game (or save, or something) icon at the top of the right hand monitor in the cockpit (the only thing you can click on), the game loads and plays fine.
It's looking very good so far - you've really captured the Ridley Scott Bladerunner vibe. One note: the ship controls are very right-handed. Maybe they could be mirrored for us Sinister players?