Thanks for playing. Some of the folders will get infected (they will have a bar under them) around every 10 seconds, you need to click on those folders to fill the bar and recover the folder. If you failed to recover them and the bar gets to zero, it's game over and the game should restart.
I understand that the disappearing cursor might be a bit unfair and I'll see what I can do for next update ^^
The cursor still disappearing on restart is indeed a bug, I'm sorry for the inconvenience. I'll try to fix it after the jam is over.