This is an interesting concept. I wonder how far you could take an idea that relies on randomness/chaos because the randomness can feel unfair/not fun. I think with careful balancing this could be pretty awesome. Maybe you can ditch the knives and make the entire thing centered around potions and actually level up your potion crafting skills and have some weird alchemy/action game where you make potions to use as weapons but sometimes there are additional chaotic effects. Cos alchemy is awesome in general :D