Try this method here, that adds some "winetrick" lines that seems to add d3d support
https://itch.io/t/268872/running-pixel-fx-designer-on-mac-with-wineskin
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For anyone who wants to try on a stable version of macos :
brew install wine
brew install winetricks
winetricks corefonts
winetricks d3dcompiler_43 <-- if d3d error
WINEARCH=win64 WINEPREFIX=~/.wine64 winecfg
WINEPREFIX=~/.wine64 wine Pixel\ FX\ Designer.exe
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