I started running this a month and change ago, which means I've had around five sessions scattered over two different games, and while I initially had my doubts -- both about the level of 'desperation' that the dice set up and the general difficulty of running the setting, I'm pleased to report that, frankly, Last Fleet is amazing. If you have a group of players who are willing to lean in on the desperation and things-going-badly because there's no way this ends well sort of scenarios, the game practically sings.
The outcomes from the various moves are well crafted, and the Pressure system is super smooth. If I have one concern, it's that XP seems to get doled out a little...irregularly, and that keep track of when it comes in has been a little tricky, but I expect that will smooth itself out with more experience.
Really enjoying this game, and looking forward to playing more of it.