I tried interpolating in RGB (turned off "Interpolate in YUV") to avoid the broken pipe error posted below. It seems to work, no crashing error. However, the resulting video flickers a lot with black frames inserted. It looks like this:
https://gfycat.com/validdependentdove
Here are small clips to illustrate how the interpolations in RGB have flickering, and no flickering in YUV.