I've played several times, and while I've neve reached the final boss, I've had a bunch of fun!
Two criticisms I have of the Muscle Boost enemy: It's really, really unclear how that ability works, and it's pretty tough to counter.
For the longest time, I assumed that the Muscle Boost ability meant that putting dice in the red spaces would boost the enemy's damage, presumably proportionally to the numbers on those dice. Needless to say, they kept murdering me. The little muscly arm icon helps, but it's not clear what that means unless you intuit that there's an associated tooltip.
Second, it's tough to counter. Unless you have a decent number of hollow dice or low-level Boost dice, there aren't many useful formations you can put dice in that cover all three spaces. It feels like covering just one or two should have some effect, but it doesn't—put all three dice in a line or just eat double damage.
Anyways, despite that I'm still enjoying myself. Trying to figure out a good strategy to use. Probably need to remove dice more often...