Perhaps try opening the .exe directly as an administrator. If you've downloaded it through the Itch Client, it will be in \AppData\Roaming\itch\apps\drive-time-radio\DriveTimeRadio
That didn't work for me either, unfortunately. And it's the same for me, Swashberry. I'm using Windows 10 Pro version 21H2. Intel CPU and NVIDIA GPU if it's possibly some hardware thing.