Controller support is limited and I haven't really worked on it but combat in the game isn't that twitchy for the most part you can even check some let's plays on YouTube. You can use melee for most of the main game and only 1 of the 3 stories in DLC is Gun focused.
But if your saying something like your hands physically can't use a keyboard and mouse due to like a disability that'll be something I'll have to look into in the future to allow more accessibility for everyone.